New Nucleobase Analogues

Biolog is an innovative and scientifically oriented enterprise based in Germany that specializes in tools for signal transduction research. The company has its focus on nucleotide chemistry, with special emphasis on cyclic nucleotide-based modulators of respective protein kinases, phosphodiesterases, ion channels, etc.
As an authorized distributor of Biolog in India, we take pride in announcing the launch of six new compounds, which hold great significance in both prokaryotic & eukaryotic systems:

Adenosine- 3', 5'- O- bisphosphate (pA-3'-p / pAp), sodium salt, Cat # A 444-10; A 444-50: Adenosine 3′,5′-diphosphate disodium salt (PAP) is used to study the kinetics and mechanisms of hydroxysteroid sulfotransferases such as SULT1A1, SULT2A1. It is an inhibitor of hydroxysteroid sulfotransferases. Additionally, it is a key component of the adenosine triphosphate (ATP) cycle and plays an important role in energy metabolism, cell signaling, and gene expression. PAP is also involved in the synthesis of DNA, RNA, and other nucleic acid components.
Adenosine- 2', 5'- O- bisphosphate (pA-2'-p / 2'-pAp), sodium salt, Cat# A 449-10, A 449-50: In pA-2'-p phosphate groups are attached to both the ribose 2' position and the ribose 5' position of adenosine. It is an inhibitor of P2Y1 and exhibits non-selective antagonism at recombinant and human platelet P2X1 receptors. pA-2'-p inhibits ADP-induced platelet shape change and aggregation but it does not affect ADP-induced inhibition of adenylyl cyclase.
2'-, 2'', 2''', 2''''- Tetra- O- methyl- cyclic tetraadenosine monophosphate (2',2'',2''',2''''-Tetra-O-Me-c-tetraAMP), sodium salt, Cat# T 066-005, T 066-025: Cyclic oligoadenylates such as c-tetraAMP were found to be novel bacterial second messengers involved in the Type III CRISPR-Cas-associated detection and degradation of invasive genetic elements in many prokaryotes. 2',2'',2''',2''''-Tetra-O-Me-c-tetraAMP is an analogue of c-tetraAMP containing O-methyl modifications in all ribose 2'-positions, which are expected to make the compound resistant to degradation by nucleases.
These products open up new avenues for research in the fields of prokaryotic & eukaryotic biological system, making them indispensable tools for the scientific community.

For further details, kindly contact us @info@biotechnolabs.com.

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