Serotonin Polyclonal Antibody Cat

Serotonin (5-hydroxytryptamine, 5-HT) is one of the most potent monoamine neurotransmitters and peripheral signaling molecules, able to act as a paracrine, endocrine, and exocrine messenger, and found stored in three main cell types. While serotonergic neurons in the nervous system, intestinal myenteric plexus, and enterochromaffin cells in the mucosa of the gastrointestinal tract can both uptake and synthesize 5-HT from its precursor L-tryptophan, blood platelets only rely upon 5-HT uptake for their stores. Serotonin is also synthesized in the pineal gland as a precursor of melatonin. Physiologically, 5-HT has complex and diverse effects on central and peripheral neuromodulation, neuroendocrine regulation, and immunological responses. In addition, it plays an important role in the biochemistry of many pathophysiological conditions such as depression, migraine, bipolar disorder, anxiety, gastrointestinal dysregulation, and cancer. Therefore, evaluating serotonergic contents and their functional expression is critical to approaching complex 5-HT activities and requires compatible experimental tools.