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Recombinant viral and human proteins are critical reagents for investigating the novel coronavirus and developing COVID-19 treatments. Proteintech offers high purity, recombinant proteins such as human ACE2 and the viral receptor binding domain (RBD) of the Spike protein (S protein) to further accelerate COVID-19 research.

SARS-CoV-2 has 4 structural components: 1) the Envelope protein (E protein), 2) Membrane glycoprotein (M protein), 3) S protein, and 4) Nucleocapsid protein (N protein). The RBD of S protein binds to Angiotensin converting enzyme-2 (ACE2) on the human cell surface to initiate viral entry. The N protein promotes helical nucleocapsid formation during viral assembly while the E and M proteins are the key structural components of SARS-CoV-2.

Recombinant viral and human proteins against SARS-CoV-2 proteins

TargetDomainCatalog numberTagHost
nucleocapsid phosphoprotein1-419aaag306766*His tagBL21(DE3)
membrane glycoprotein101-222aaag306926*His tagBL21(DE3)
spike protein-RBD319-541aaag30689GSTBL21
envelope protein1-75aaag30690GSTBL21
ACE2 (Binding domain) fusion protein30-356aaag306836*His tagPET28a
ACE2 (C-terminal) fusion protein392-744aaag155546*His tagPET28a
ACE2 fusion protein30-356aaag30686GSTPGEX-4T