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Functional Factor P Assay

By: Team BTL Biotechno Labs Pvt. Ltd.

Factor P, also referred to as Properdin, has an important role in the amplification loop of the complement system. Upon binding to C3bBb, it acts as a stabilizer, extending the half-life of C3bBb significantly. In addition, it inhibits the factor H-mediated cleavage of C3b by factor I, thereby increasing C3b formation and positively regulating the complement cascade response. As an up-regulator of the complement system, properdin is of interest to pharmaceutical companies looking for therapeutic targets as well as academic groups studying the amplification loop.

BTL Biotechno Labs Pvt. Ltd. is an exclusive channel partner of SVAR Life Science in India. We are committed to being the most reliable supplier of life science research products in the entire Indian market and serving the scientific community by providing innovative, reliable, and high-quality research products at an affordable price.

As a distributor of SVAR Life Science, we provide their unique Factor-P Functional Assay Kit to the scientific community working on complement system pathways for accurately measuring the levels of properdin and determining its functionality. In addition, the assays can easily be adapted to more in-depth studies, granting a closer look at the amplification loop. In the functional factor P assay, FP is bound by the capture antibody, just as in the quantitative assay. A reference serum is then added. If the initial sample contains functional properdin, C3 from the reference will be cleaved to C3b. An enzyme-conjugated detection antibody is used to detect C3b in the well.