
PEG Linkers
The term ‘PEGylation’ can be defined as the covalent attachment of polyethylene glycol chains to bioactive substances. Polyethylene glycol (PEG) is a non-ionic polyether compound and has been widely used in common applications in cosmetics and pharmaceuticals for its excellent properties as a solvent, plasticizer, surfactant, base, and lubricant. In pharmaceutical applications, PEG has several advantages, as it increases the circulation time of the drugs and decreases their immunogenicity. PEG increases the molecular weight (MW) of pharmaceutical products such as proteins or peptides, decreasing kidney clearance and protecting them from proteolytic degradation, thus altering their pharmacokinetic profile.
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