Chondrex Inc: Collagen Specialists!!!!!!!!!
Chondrex, Inc. provides various species and types of Collagen for various purposes such as immunization for collagen-induced arthritis in experimental animals, tissue engineering, cell culture, and antibody assays. They have a wide product profile for this which includes immunization Grade: Type I, II, III, IV, IX, & XI Collagen from Bovine, Chick, Human, Mouse, Porcine, and Rat, Cell Culture Grade Collagen, ELISA Grade Collagen, T-Cell Proliferation Grade Collagen, CB Peptides of Type II Collagen.
The company also provides reagents for developing animal models for various diseases like Allergy, Arthritis (Adjuvant Induced, Collagen Induced, Collagen Antibody Arthritis), Nephritis, Sjögren’s Syndrome, Colitis (DSS), Sepsis, Alport Syndrome etc.
Cytokines are a class of small soluble protein molecules participating in various cell types in autocrine, paracrine, and endocrine cell signalling. Within the immune system, the cytokine microenvironment plays specific and important roles in naive CD4+ T-cell differentiation in response to a different antigen. Thus, cytokines are target molecules for new therapeutics to attenuate or control inflammatory responses in these diseases. Chondrex, Inc. provides cytokine detection ELISA kits for mouse and human samples to study the complicated physiological and pathological roles of cytokines in systemic inflammatory reactions, including TNF-α, IL-6, IL-4, IFN-γ, IL-1β, IL-10, IL-17, TGF-β1, VEGF, IL-2, IL-13. Further, Chondrex Inc provides antibodies against many antigens like Collagen Antibodies (Type I, II, IV, V, & IX) & DNA Antibodies, House Dust Mite Antibodies, HMGB1 Antibodies, OVA Antibodies, CD9 & CD63 Antibodies, CTLA4 Antibodies, PD-1& PD-L1 Antibodies, Ro60 Antibodies etc.
Connective tissue comprises cells surrounded by the extracellular matrix (ECM), a complex mixture of collagens and glycosaminoglycans (GAGs). Collagen, the most abundant protein family in connective tissues, plays a critical role in forming the ECM. Chondrex, Inc. provides various kits for ECM analysis like Glycosaminoglycans Assay Kit, DNA Assay Kit, Sirius Red/Fast Green Collagen Semi-Quantitative Kit, Hydroxyproline Assay Kit, Type I or II Collagen ELISA Kits etc.
Apart from all these products, the company also supplies Chemokine detection ELISA kits. Chemokines are the proteins that induce inflammatory cell migration and activation by binding to specific G-protein-coupled cell-surface receptors expressed on different types of leukocytes. Elevated chemokine levels are observed in various inflammatory diseases. In the case of malignant cancers, chemokines play roles both in inducing immune-cell infiltration as well as in cancer-cell proliferation.